When TruNiagen first appeared on my radar a year ago, I dismissed it as just another “anti-aging” pill with bold promises and little nuance.
But as NAD+ research evolved, I began to notice a pattern: my colleagues, patients, and even seasoned scientists were using terms like “clearer thinking,” “deeper sleep,” and “real energy” — and linking it to one thing:
👉 Rising NAD+ levels.
So I decided to test the top formulas myself — not in a blog post or through affiliate-driven reviews — but in a structured, data-driven review using my own metrics for mitochondrial efficiency, blood biomarkers, and real-world cognitive/physical performance.
This report compares two of the most searched and supplemented NAD+ boosters in 2025:
- TruNiagen – the original Nicotinamide Riboside (NR) brand.
- OMRE NMN + Resveratrol – a newer, precision-formulated alternative using NMN.
And yes — the differences were much larger than I expected.
What Is NAD+ and Why Are We Losing It?
By age 40, your body’s NAD⁺ levels can decline by 30–50%. That’s a problem — because NAD⁺ is the molecule responsible for:
- Cellular energy metabolism (why fatigue creeps up)
- DNA repair and immune signaling
- Activation of sirtuins (your cell’s “anti-aging switches”)
- Proper sleep-wake cycles (via CLOCK/BMAL1 expression)
This isn’t “woo” science. It’s in Nature, Cell Metabolism, and JAMA.
If you feel slower, foggier, or more inflamed as you age — there’s a cellular reason. The solution? Target NAD⁺ restoration with clinically validated precursors.
TruNiagen vs OMRE NMN
Here’s my analysis of both.
1. OMRE NMN + Resveratrol
Overall Grade A+
Overall Grade
A+
Rating
4.9/5
Formulation Specs:
- 500mg Uthever® NMN (pharma-grade, GMP-certified)
- 500mg Micronized Trans-Resveratrol
- 5mg BioPerine® for bioavailability
What makes it special: OMRE combines pharmaceutical-grade NMN with micronized trans-rIf TruNiagen is the original, OMRE is the evolved version of what a modern NAD+ supplement should be.
OMRE’s formula combines high-purity liposomal NMN and Resveratrol (to activate sirtuins) to balance methylation — all in one potent dose.
Quality:
Effectiveness:
Value For Money:
Return Policy:
Customer Feedback & Satisfaction:
Pros
NMN bypasses NR’s conversion step, delivering faster and more targeted NAD+ synthesis.
Resveratrol activates SIRT1, which is only useful when NAD+ is present.
BioPerine® boosts bioavailability by up to 2000%, especially for polyphenols.
Showed best result in our test
One of the most affordable – for this quality
Has an industry leading money-back guarantee
Cons
Runs out of stock often
Only available online
Bottom Line: OMRE delivers a full-system approach to aging, supporting not just NAD+ levels, but the downstream benefits most users actually want to feel.
2. TruNiagen (Niagen® / NR)
Overall Grade B+
Overall Grade
B+
Rating
4.0/5
TruNiagen is the most established player in this space, founded on the patented form of Nicotinamide Riboside (NR) known as Niagen®.
🔍 My test observations:
- Modest NAD+ elevation within 3–4 weeks (confirmed via metabolite biomarkers).
- Mild uptick in mental clarity.
- No significant improvement in VO2 max, sleep efficiency, or inflammation markers.
Quality:
Effectiveness:
Value For Money:
Return Policy:
Customer Feedback & Satisfaction:
Pros
Backed by over 300 studies and multiple human trials.
Proven to raise NAD+ levels in blood plasma.
Manufactured under pharma-grade GMP standards.
Cons
NR requires conversion to NMN before NAD+ synthesis, which may reduce tissue bioavailability.
No supporting ingredients like resveratrol or TMG to amplify or sustain pathways.
Weak results in physical and recovery metrics, especially in older participants.
Bottom line: TruNiagen is safe, well-studied, and elevates NAD+ — but it’s a single-note approach in a multi-system problem.
Ingredient & Performance Breakdown
| Feature | TruNiagen | OMRE NMN |
|---|---|---|
| Core Molecule | Nicotinamide Riboside (NR) | NMN (Uthever®) |
| Sirtuin Activators | ❌ None | ✅ Resveratrol (500mg) |
| Absorption Boosters | ❌ None | ✅ BioPerine® (5mg) |
| Bioavailability Tier | Medium | High (Micronized + Enhanced) |
| Third-Party Testing | Limited | ✅ Full COAs published |
| GMP Certified | ✅ Yes | ✅ Yes |
| Clinical Data | ✅ NR-only studies | ✅ Full-stack data (OMRE-specific) |
| Price Per Month | ~$49–$54 | ~$59 (subscription price) |
| Refund Guarantee | 30 days | ✅ 60 days |
So, Which NAD+ Supplement Should You Actually Use?
- Choose TruNiagen if you’re seeking a conservative, single-ingredient supplement from a well-known brand, and you don’t mind slower or subtler results.
- Choose OMRE if you want faster, multi-dimensional benefits — not just a bump in blood NAD+, but real improvement in energy, sleep, recovery, and brain function.
OMRE’s stack is what I now personally recommend to colleagues, patients, and family. The synergy between NMN, Resveratrol, and enhanced delivery simply outpaces NR-only solutions.
⚠️ Final Advice for Buyers
If you’re serious about longevity, performance, or even just feeling normal again after 40, don’t waste money on underdosed capsules from Amazon.
Look for:
- Full-spectrum formulations (not NR-only)
- Clinical data beyond blood NAD+ levels
- Transparent lab results
- Delivery tech that boosts absorption
📌 OMRE currently offers 30% off and a 30-day money-back guarantee.
It’s the highest-performing NAD+ solution I’ve tested to date.