I evaluated 15 of the most popular NAD+ supplements on the market. You’ve probably come across them like Cata-Kor, Renue, Zoone, Thorne, and more.
After turning 45, I personally began to notice shifts in my energy levels, cognitive sharpness, and metabolism.
As a physician focused on longevity research, I recognized these as likely signs of declining NAD+—a vital molecule involved in cellular energy and repair.
This started my three-year deep dive into NMN (Nicotinamide Mononucleotide) supplements. I’ve spoken with leading researchers, personally tested numerous products, and reviewed hundreds of anecdotal reports to find which supplements may truly support NAD+ levels effectively.
By the End of This Report, You’ll Know Exactly How to:
- Restore consistent energy in 7–14 days by replenishing declining NAD⁺ levels*
- Eliminate daily brain fog by optimizing mitochondrial efficiency for sharper focus*
- Fall asleep faster and improve overnight cellular recovery in as little as 2 weeks*
- Understand which NAD⁺ strategies actually activate sirtuins and why most fail*
- Avoid the 3 ingredient traps that waste your money and stall results*
*Timelines are based on human clinical and preclinical studies on NAD⁺ restoration, mitochondrial repair, and cellular energy metabolism published in peer-reviewed journals including Cell, Nature Aging, and JAMA
Why NAD+ Matters Now More Than Ever
NAD+ (Nicotinamide Adenine Dinucleotide) declines with age—often by as much as 50% by your 50s. This has implications for energy, cellular repair, and age-associated biological processes.
Over the years, research has suggested NMN supplementation might help restore NAD+ and support various health markers. NMN converts to NAD+ in the body, but not all supplements are equal—differences in quality, absorption, and formulation are key.
4 Best NMN Supplements of 2025 (Experience & Analysis)
These products stood out in my review for their potential to improve energy, focus, sleep, and general well-being.
1. OMRE NMN + Resveratrol — Overall Grade: S
What makes it special: OMRE combines pharmaceutical-grade NMN with micronized trans-resveratrol and BioPerine® in a scientifically optimal ratio. This thoughtful formulation demonstrates a sophisticated understanding of cellular biochemistry.
My experience: Within three weeks of starting OMRE, I noticed a distinct improvement in my afternoon energy levels—typically my lowest point of the day. By week six, my Oura Ring data showed a 16% improvement in deep sleep, and my recovery from weightlifting sessions accelerated noticeably.
Formula breakdown:
- 500mg Uthever® premium NMN (pharmaceutical grade)
- 500mg micronized trans-resveratrol
- 5mg BioPerine® for enhanced absorption
- Third-party tested with published results
Among a group of 15 observed users, 13 reported notable changes. These included potential improvements in inflammation, glucose response, and aerobic capacity.
Why it tops the list: While other products contain quality NMN, OMRE’s formula stands out for understanding the synergistic relationship between NMN and resveratrol. The addition of BioPerine® significantly enhances absorption of the resveratrol component—a compound that typically has poor bioavailability unless properly formulated.
Editor’s note: Since receving extensive media coverage, OMRE’s customer support has warned that it might go out of stock.
2. DoNotAge NMN Supplement — Overall Grade: A+
What sets it apart: DoNotAge offers a pure NMN powder that gives you complete control over your dosing. This flexibility allows for personalized protocols based on your specific needs and response.
My experience: The powder format initially seemed inconvenient, but I came to appreciate the flexibility in adjusting my dosage. I noticed moderate improvements in mental clarity and physical stamina after about four weeks of consistent use.
Formula breakdown:
- Pure NMN powder
- No fillers or additives
- Third-party tested for purity
- Allows for flexible dosing
Pros:
- Excellent purity levels verified by independent testing
- Cost-effective on a per-gram basis
- Flexibility to adjust dosage based on personal response
- Simple, clean formulation
Cons:
- Powder format requires careful measurement
- Lacks synergistic ingredients like Resveratrol
- Taste can be off-putting for some users
- Requires more effort to incorporate into daily routine
Bottom line: DoNotAge provides a high-quality, pure NMN powder that’s ideal for those who value flexibility and simplicity. However, it lacks the complementary ingredients and convenience of our top choice.
3. Tru Niagen (Nicotinamide Riboside) — Overall Grade: A
What makes it unique: While not technically an NMN supplement, Tru Niagen deserves mention for its pioneering work with Nicotinamide Riboside (NR), another NAD+ precursor with significant research behind it.
My experience: Tru Niagen produced subtle improvements in my energy levels, particularly during the first month. The effects weren’t as pronounced as with OMRE, but the convenience of the capsule format was a definite plus for daily compliance.
Formula breakdown:
- Patented form of Nicotinamide Riboside
- Clean capsule formulation
- Extensively researched by ChromaDex
- FDA safety notifications
Pros:
- Backed by multiple patents and scientific studies
- Well-established company with good manufacturing standards
- Easy-to-take capsule format
- Solid safety profile
Cons:
- Uses NR instead of NMN (some research suggests NMN may be more effective)
- Limited complementary ingredients
- Higher cost per serving compared to some alternatives
- May have lower bioavailability than newer formulations
Bottom line: Tru Niagen offers a well-researched NR supplement from a reputable company, but may not provide the same benefits as more advanced NMN formulations with synergistic ingredients.
4. Renue By Science — Overall Grade: A
What sets it apart: Renue By Science offers an innovative sublingual delivery system designed to improve absorption by bypassing digestive breakdown.
My experience: The sublingual format was initially awkward, but I adapted quickly. I noticed faster onset of effects compared to capsules—typically feeling a subtle energy boost within 30-45 minutes after taking it.
Formula breakdown:
- Pure NMN in sublingual tablet
- Designed to dissolve under the tongue
- Good manufacturing standards
- Focused on absorption efficiency
Pros:
- Unique delivery method potentially improves bioavailability
- Pure, high-quality NMN
- Faster onset of effects
- Good user feedback on efficacy
Cons:
- Limited research specifically supporting sublingual NMN delivery
- No complementary ingredients to enhance effects
- Can be less convenient than swallowing a capsule
- Some users report taste issues
Bottom line: Renue By Science offers an innovative approach to NMN supplementation that may improve absorption, but lacks the synergistic ingredients found in our top choice.
5. Thorne ResveraCel — Overall Grade: A
What sets it apart: A multi-ingredient formulation using Nicotinamide Riboside (NR) with resveratrol, quercetin, and TMG to address multiple longevity pathways.
My experience: I saw modest improvements in energy and mood, though not as pronounced as with NMN-based formulas. Patients appreciated the “one capsule, multi-pathway” approach but needed higher doses for optimal results.
Formula breakdown:
- 300mg Niagen® NR
- 150mg resveratrol
- 250mg quercetin phytosome
- 50mg TMG
Pros:
- Well-rounded formulation
- Good brand reputation and clean manufacturing
- Includes ingredients that may reduce NAD+ degradation (quercetin)
Cons:
- Uses NR instead of NMN (less direct precursor)
- Lower active dosages than ideal
- No delivery or absorption enhancers
Bottom line: A solid, beginner-friendly option with broad support for cellular health—but doesn’t match the clinical impact of stronger NMN-based formulas.
6. Cata-Kor (previously Reus Research) Liposomal NAD+ — Overall Grade: B+
What sets it apart: Uses liposomal encapsulation to claim up to 9.3x better NAD+ absorption compared to traditional capsules.
My experience: The science on liposomal delivery is promising, but Cata-Kor provides little third-party data. While some patients reported better energy, results were inconsistent and harder to replicate than with more thoroughly validated formulas.
Formula breakdown:
- Proprietary LipoNAD+ blend (500mg per serving)
- Liposomal delivery system for absorption
Pros:
- Enhanced theoretical bioavailability
- Convenient single-serve packaging
- Clean-label formulation
Cons:
- Limited public data on ingredient purity or bioavailability
- No synergistic compounds like resveratrol or quercetin
- Lack of clinical dosage transparency
Bottom line: Interesting delivery concept, but without published data or synergistic ingredients, it feels like an untested concept designed to sell products.
7. Zoone NR1000 — Overall Grade: C+
What sets it apart: A basic NR supplement aimed at boosting energy and mitochondrial function, marketed heavily on affordability.
My experience: While it’s accessible, the formulation is bare-bones. Patients didn’t report meaningful results beyond a placebo-level energy bump.
Formula breakdown:
- 300mg NR
- Standard capsule delivery
- Basic B-vitamin support
Pros:
- Affordable and easy to find
- Simple, no-frills formulation
Cons:
- No complementary ingredients
- No enhanced absorption strategy
- Minimal clinical results observed
Bottom line: It’s a starter NAD+ product, but if you’re looking for clinical results, not your thing.
Other brands we tested, but did not make it to our top 7:
They either lose out in terms of value, documentation or result:
- Partiqlar
- Qualia
- Selerb
- Thinbi
- Codeage
- Donotage
- Just Ingredients
- Arete Nutra
Why Most People Don’t Experience Results from NMN
In my practice, I’ve found several critical factors that determine whether patients actually benefit from NMN supplementation:
1. Insufficient Dosage
Many products contain dosages (100-125mg) far below what clinical research suggests is effective (500-600mg daily). This “pixie dusting” of ingredients allows companies to claim active compound content while minimizing costs—but provides minimal benefits.
2. Poor Absorption
The molecular structure of these compounds presents absorption challenges. Without specific delivery systems (like micronization, liposomal delivery, or absorption enhancers), much of the active compound may pass through your system unutilized.
3. Missing Synergistic Compounds
These cellular rejuvenation molecules work within complex biochemical pathways. Research indicates compounds like resveratrol significantly enhance effectiveness by activating the sirtuin pathways that utilize NAD+.
4. Inconsistent Quality Control
My analysis revealed alarming variations in actual active ingredient content between products—and even between batches of the same product. Without rigorous third-party testing, quality is frequently compromised.
The Right Approach to NAD+ Optimization
Based on current research and my experience, here’s what I recommend to my patients:
Allow sufficient time for cellular changes to manifest—while some effects may appear within weeks, comprehensive benefits typically develop over 2-3 months
Choose comprehensive formulations that address both NAD+ production (via quality precursors) and sirtuin activation (via compounds like resveratrol)
Verify third-party testing to ensure you’re actually getting what you pay for—particularly important with expensive compounds
Look for bioavailability enhancers such as BioPerine®, liposomal technology, or micronization
Consider timing and dosage carefully—morning administration on an empty stomach typically yields optimal absorption
The Verdict
After extensive testing and research, OMRE NMN + Resveratrol stands out as the most comprehensive and effective NMN supplement. Its thoughtful combination of high-quality NMN, micronized resveratrol, and absorption enhancers delivers noticeable improvements in energy, cognitive function, and recovery.
However, individual results will vary. Genetics, age, baseline health, and consistency all matter. NMN science is advancing, and early findings are promising for healthy aging.
Note: The charts are based on personal testing, results may vary.