I evaluated 15 of the most popular NAD+ supplements on the market. You’ve probably come across them like Cata-Kor, Renue, Zoone, Thorne, and more.
After turning 45, I personally began to notice shifts in my energy levels, cognitive sharpness, and metabolism.
As a physician focused on longevity research, I recognized these as likely signs of declining NAD+—a vital molecule involved in cellular energy and repair.
This started my three-year deep dive into NMN (Nicotinamide Mononucleotide) supplements. I’ve spoken with leading researchers, personally tested numerous products, and reviewed hundreds of anecdotal reports to find which supplements may truly support NAD+ levels effectively.
By the End of This Report, You’ll Know Exactly How to:
- Restore consistent energy in 7–14 days by replenishing declining NAD⁺ levels*
- Eliminate daily brain fog by optimizing mitochondrial efficiency for sharper focus*
- Fall asleep faster and improve overnight cellular recovery in as little as 2 weeks*
- Understand which NAD⁺ strategies actually activate sirtuins and why most fail*
- Avoid the 3 ingredient traps that waste your money and stall results*
*Timelines are based on human clinical and preclinical studies on NAD⁺ restoration, mitochondrial repair, and cellular energy metabolism published in peer-reviewed journals including Cell, Nature Aging, and JAMA
Why NAD+ Matters Now More Than Ever
NAD+ (Nicotinamide Adenine Dinucleotide) declines with age—often by as much as 50% by your 50s. This has implications for energy, cellular repair, and age-associated biological processes.
Over the years, research has suggested NMN supplementation might help restore NAD+ and support various health markers. NMN converts to NAD+ in the body, but not all supplements are equal—differences in quality, absorption, and formulation are key.
9 Best NMN Supplements of 2025 (Experience & Analysis)
These products stood out in my review for their potential to improve energy, focus, sleep, and general well-being.
1. OMRE NMN + Resveratrol
Overall Grade S
Overall Grade
S
Rating
4.9/5
OVERALL ANALYSIS
What makes it special: OMRE‘s combination of pharmaceutical-grade NMN and micronized resveratrol places it among the best NAD supplement brands. It also ranks consistently high in recent NAD+ supplement reviews and NMN supplement reviews.
My experience: Within three weeks of starting OMRE, I noticed a distinct improvement in my afternoon energy levels—typically my lowest point of the day. By week six, my Oura Ring data showed a 16% improvement in deep sleep, and my recovery from weightlifting sessions accelerated noticeably.
Formula breakdown:
- 500mg Uthever® premium NMN (pharmaceutical grade)
- 500mg micronized trans-resveratrol
- 5mg BioPerine® for enhanced absorption
- Third-party tested with published results
Lab Testing: Independent analysis confirmed 98% label accuracy and no detectable heavy metals. The use of micronized resveratrol likely improves its absorption, which tends to be limited in standard forms.
What Sets It Apart: OMRE’s formulation demonstrates a sophisticated understanding of cellular biochemistry—particularly how advanced NAD+ precursors and resveratrol work synergistically. While the primary compound directly increases NAD+ levels, resveratrol activates SIRT1 (a longevity-associated protein that requires NAD+ to function). The addition of BioPerine® significantly enhances absorption of the resveratrol component.
This product isn’t just a strong NMN—it’s arguably the best NAD+ and resveratrol supplement on the market right now.
Quality:
Effectiveness:
Value For Money:
Return Policy:
Customer Feedback & Satisfaction:
Pros
Excellent bioavailability
Transparent lab test & documentation
Showed best result in our test
One of the most affordable – for this quality
High reviews on both Amazon and their store
Has an industry leading money-back guarantee
Cons
Runs out of stock often
Editor’s note: Since receving extensive media coverage, OMRE’s customer support has warned that it might go out of stock.
2.DoNotAge NMN Supplement
by Donotage
Overall Grade A
Overall Grade
A
Rating
4.2/5
OVERALL ANALYSIS
What sets it apart: DoNotAge offers a pure NMN powder that gives you complete control over your dosing. This flexibility allows for personalized protocols based on your specific needs and response.
My experience: The powder format initially seemed inconvenient, but I came to appreciate the flexibility in adjusting my dosage. I noticed moderate improvements in mental clarity and physical stamina after about four weeks of consistent use.
Formula breakdown:
- Pure NMN powder
- No fillers or additives
- Third-party tested for purity
- Allows for flexible dosing
Quality:
Effectiveness:
Value For Money:
Return Policy:
Customer Feedback & Satisfaction:
Pros
Good purity levels
Flexible dosing options
Cost-effective per gram
Cons
Powder format less convenient
No complementary ingredients
Taste can be off-putting
Bottom line: DoNotAge provides a high-quality, pure NMN powder that’s ideal for those who value flexibility and simplicity. However, it lacks the complementary ingredients and convenience of our top choice.
3.TruNiagen (Nicotinamide Riboside)
by TruNiagen
Overall Grade A-
Overall Grade
A-
Rating
4.2/5
OVERALL ANALYSIS
THE BOTTOM LINE
While not technically an longevity supplement, Tru Niagen NAD is worth mentioning as it uses Nicotinamide Riboside (NR), another NAD+ precursor. It has several patents and studies behind it, but research suggests NAD+ boosters may have better bioavailability.
The product is well-manufactured but provides fewer complementary ingredients and a different mechanism of action compared to our top choices.
Quality:
Effectiveness:
Value For Money:
Return Policy:
Customer Feedback & Satisfaction:
Pros
Patented form of NR
Well-researched company
Good manufacturing standards
Cons
Uses NR instead of NAD+ boosters
Limited complementary ingredients
Higher cost per serving
Bottom line: Tru Niagen NAD offers a well-researched NR supplement from a reputable company, but may not provide the same benefits as more advanced NMN formulations with synergistic ingredients.
4.Renue By Science
by Renue
Overall Grade B+
Overall Grade
B+
Rating
4.0/5
OVERALL ANALYSIS
THE BOTTOM LINE
Alive By Science offers a sublingual NAD+ boosting tablet designed to dissolve under the tongue for better absorption. While this delivery method is interesting, clinical evidence specifically supporting sublingual NAD+ boosters absorption is limited.
The product contains pure NAD+ boosters but lacks supporting ingredients and may be less convenient than traditional capsules.
Quality:
Effectiveness:
Value For Money:
Return Policy:
Customer Feedback & Satisfaction:
Pros
Pure NAD+ boosters
Unique delivery method
Good manufacturing standards
Cons
Limited research on sublingual delivery
No complementary ingredients
Can be inconvenient to use
5. Thorne ResveraCel
by Thorne
Overall Grade B
Overall Grade
B
Rating
3.9/5
OVERALL ANALYSIS
What sets it apart: A multi-ingredient formulation using Nicotinamide Riboside (NR) with resveratrol, quercetin, and TMG to address multiple longevity pathways.
My experience: I saw modest improvements in energy and mood, though not as pronounced as with NMN-based formulas. Patients appreciated the “one capsule, multi-pathway” approach but needed higher doses for optimal results.
Formula breakdown:
- 300mg Niagen® NR
- 150mg resveratrol
- 250mg quercetin phytosome
- 50mg TMG
Bottom line: A solid, beginner-friendly option with broad support for cellular health—but doesn’t match the clinical impact of stronger NMN-based formulas.
Quality:
Effectiveness:
Value For Money:
Return Policy:
Customer Feedback & Satisfaction:
Pros
Well-rounded formulation
Good brand reputation and clean manufacturing
Includes ingredients that may reduce NAD+ degradation (quercetin)
Cons
Uses NR instead of NMN (less direct precursor)
Lower active dosages than ideal
No delivery or absorption enhancers
6. Cata-Kor (previously Reus Research) Liposomal NAD+
by Reus Research
Overall Grade B-
Overall Grade
B-
Rating
3.6/5
OVERALL ANALYSIS
What sets it apart: Uses liposomal encapsulation to claim up to 9.3x better NAD+ absorption compared to traditional capsules.
My experience: The science on liposomal delivery is promising, but Cata-Kor provides little third-party data. While some patients reported better energy, results were inconsistent and harder to replicate than with more thoroughly validated formulas.
Formula breakdown:
- Proprietary LipoNAD+ blend (500mg per serving)
- Liposomal delivery system for absorption
Bottom line: Interesting delivery concept, but without published data or synergistic ingredients, it feels like an untested concept designed to sell products.
Quality:
Effectiveness:
Value For Money:
Return Policy:
Customer Feedback & Satisfaction:
Pros
Enhanced theoretical bioavailability
Convenient single-serve packaging
Cons
Limited public data on ingredient purity or bioavailability
No synergistic compounds like resveratrol or quercetin
Lack of clinical dosage transparency
7. Zoone NR1000
by Zoone
Overall Grade C+
Overall Grade
C+
Rating
3.4/5
OVERALL ANALYSIS
What sets it apart: A basic NR supplement aimed at boosting energy and mitochondrial function, marketed heavily on affordability.
My experience: While it’s accessible, the formulation is bare-bones. Patients didn’t report meaningful results beyond a placebo-level energy bump.
Formula breakdown:
- 300mg NR
- Standard capsule delivery
- Basic B-vitamin support
Bottom line: It’s a starter NAD+ product, but if you’re looking for clinical results, not your thing.
Quality:
Effectiveness:
Value For Money:
Return Policy:
Customer Feedback & Satisfaction:
Pros
Affordable and easy to find
Simple, no-frills formulation
Cons
No complementary ingredients
No enhanced absorption strategy
Minimal clinical results observed
8. Rho Nutrition Liposomal NAD+
by Rho
Overall Grade C+
Overall Grade
C+
Rating
3.4/5
OVERALL ANALYSIS
What sets it apart: Rho’s Liposomal NAD+ stands out for its high bioavailability due to liposomal encapsulation, targeting better absorption without injections.
My experience: After consistent use for 6 weeks, I noticed some improvement in energy stability and mental alertness. The liquid format is both a pro and a con—easy to dose, but less convenient to carry.
Formula breakdown:
NAD+ (not NMN or NR)
Liposomal encapsulation for enhanced absorption
Sugar-free, vegan, keto, non-GMO
No additives, third-party tested
Bottom line:
Rho delivers a potent, bioavailable NAD+ solution but the lack of robust support and funky flavor might turn some users off.
Quality:
Effectiveness:
Value For Money:
Return Policy:
Customer Feedback & Satisfaction:
Pros
Clinically inspired liposomal delivery
Clear boost in energy and cognitive sharpness
Cons
Liquid format less portable
Taste can be divisive
Weak refund support if purchased outside their site
9. Wonderfeel Youngr™ NMN
by Zoone
Overall Grade C
Overall Grade
C
Rating
3.2/5
OVERALL ANALYSIS
What sets it apart: It’s not just NMN—it’s fortified with antioxidants like ergothioneine, hydroxytyrosol, and resveratrol for sirtuin activation.
My experience:
After weeks, I saw a pronounced increase in morning energy, faster post-workout recovery, and improved sleep.
Formula breakdown:
900mg NMN per serving
Includes ergothioneine, resveratrol, hydroxytyrosol, and Vitamin D3
Vegan, gluten-free, third-party tested
Patented and designed for bioavailability
Bottom line: It’s a starter NAD+ product, but if you’re looking for clinical results, not your thing.
Quality:
Effectiveness:
Value For Money:
Return Policy:
Customer Feedback & Satisfaction:
Pros
Broad-spectrum formulation with cellular antioxidants
Strong research and formulation credibility
Refillable, eco-conscious packaging
Cons
Higher price point
Subscription logistics may frustrate some
International delivery delays noted
Other brands we tested, but did not make it to our top 9:
They either lose out in terms of value, documentation or result:
- Partiqlar
- Qualia
- Selerb
- Thinbi
- Codeage
- Donotage
- Just Ingredients
- Arete Nutra
Why Most People Don’t Experience Results from NMN
In my practice, I’ve found several critical factors that determine whether patients actually benefit from NMN supplementation:
1. Insufficient Dosage
Many products contain dosages (100-125mg) far below what clinical research suggests is effective (500-600mg daily). This “pixie dusting” of ingredients allows companies to claim active compound content while minimizing costs—but provides minimal benefits.
2. Poor Absorption
The molecular structure of these compounds presents absorption challenges. Without specific delivery systems (like micronization, liposomal delivery, or absorption enhancers), much of the active compound may pass through your system unutilized.
3. Missing Synergistic Compounds
These cellular rejuvenation molecules work within complex biochemical pathways. Research indicates compounds like resveratrol significantly enhance effectiveness by activating the sirtuin pathways that utilize NAD+.
4. Inconsistent Quality Control
My analysis revealed alarming variations in actual active ingredient content between products—and even between batches of the same product. Without rigorous third-party testing, quality is frequently compromised.
The Right Approach to NAD+ Optimization
Based on current research and my experience, here’s what I recommend to my patients:
Allow sufficient time for cellular changes to manifest—while some effects may appear within weeks, comprehensive benefits typically develop over 2-3 months
Choose comprehensive formulations that address both NAD+ production (via quality precursors) and sirtuin activation (via compounds like resveratrol)
Verify third-party testing to ensure you’re actually getting what you pay for—particularly important with expensive compounds
Look for bioavailability enhancers such as BioPerine®, liposomal technology, or micronization
Consider timing and dosage carefully—morning administration on an empty stomach typically yields optimal absorption
The Verdict
After extensive testing and research, OMRE NMN + Resveratrol stands out as the most comprehensive and effective NMN supplement. Its thoughtful combination of high-quality NMN, micronized resveratrol, and absorption enhancers delivers noticeable improvements in energy, cognitive function, and recovery.
However, individual results will vary. Genetics, age, baseline health, and consistency all matter. NMN science is advancing, and early findings are promising for healthy aging.
Why Shouldn’t You Buy NAD Supplement From Amazon?
Don’t buy NAD+ supplements from Amazon—period.
Many are fake, underdosed, or degraded due to poor storage.
Third-party testing is often missing or falsified, and Amazon doesn’t guarantee authenticity.
You could be swallowing sugar pills—or worse. For something that affects your cellular health, don’t gamble on convenience.
Buy direct from trusted brands with verified purity.